May 31st, 2025

As of the last update I posted, only a few of the original 1000 mice remained alive, so there was really nothing of significance to report when they died. I was therefore planning to hold off on other updates until there was a good body of statistical analysis of our data, so that I'd be able to say something interesting. However, our work on that aspect has been a little delayed due to our data scientists' other commitments, so I have been urged to post this anyway.

In a nutshell: the last mouse died on February 12th, and the final survival curves are attached. As I noted in the last update, we have what I think we can call a "qualified win" wirth this study - we definitely demonstrated that damage-repair treatments can have additive impact on mouse lifespan when starting in middle age, and we learned a lot about what to do in the next study (mainly, to include twice as many treatments), but on the other hand we only achieved about the same amound of life extension that has been achieved by non-repair means (specifically, calorie restriction and its mimetics) for decades. So, we are desperate to get the next study kicked off!